Which of the following is NOT considered a sign of poisoning?

Fever is not typically considered a direct sign of poisoning. While fever may occur in certain situations—such as infections or other medical conditions—it does not specifically indicate poisoning. Poisoning usually manifests through more immediate and recognizable symptoms related directly to the toxin involved.

In contrast, skin discoloration, diarrhea, and vomiting are commonly associated with various types of poisoning. Skin discoloration can indicate an allergic reaction or the effect of a poison on the body, diarrhea may be the body's way of expelling toxins, and vomiting is a frequent response to ingesting poison as the body attempts to rid itself of harmful substances. Therefore, among the options given, fever stands apart as it generally suggests a different medical issue or response rather than a direct sign of poisoning.